{"product_id":"mass-spectrometric-analysis-of-oligonucleotide-and-dna-adducts","title":"Mass Spectrometric Analysis of Oligonucleotide and DNA Adducts","description":"The assignment of the sites of modification by different carcinogens within a target sequence is a very important topic in cancer etiology and a critical part in the analysis of DNA adducts is to determine the site and frequency of modification on the DNA strands in order to better understand the relationship between the chemical behavior of different carcinogens and mutation hot spots. The initial focus was on the analysis of DNA adducts as ?monomeric units?, i.e., nucleosides or nucleotides. In order to correlate the adducts formation and gene sequence, it is necessary to have a fast and accurate methodology for structural characterization of oligonucleotide- carcinogen adducts from in vitro and in vivo sources using on-line separation coupled with MS or tandem MS. The aim of this book?s research has been to develop HPLC-MS methodology for the analysis of DNA adducts in the form of oligonucleotides. To achieve this goal, a thorough literature review was conducted and a systematic approach with carefully designed experiments was carried out along with a discussion on presents the future prospects of the research.\u003cbr\u003eASIN: 3639146859\u003cbr\u003eVSKU: BVV.3639146859.G\u003cbr\u003eCondition: Good\u003cbr\u003eAuthor\/Artist:Liao, Qing\u003cbr\u003eBinding: Paperback\u003cbr\u003e\u003cb\u003eNote:\u003c\/b\u003e Any images shown are stock photographs and product may differ from what is shown.  \u003cbr\u003e\u003cb\u003eCondition Notes\u003c\/b\u003e: The item shows wear from consistent use, but it remains in good condition and works perfectly. All pages and cover are intact  including the dust cover, if applicable . Spine may show signs of wear. Pages may include limited notes and highlighting. May NOT include discs, access code or other supplemental materials.  \u003cbr\u003e","brand":"Blue Vase Books","offers":[{"title":"Default Title","offer_id":43357940777021,"sku":"BVV.3639146859.G","price":67.4,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0589\/4225\/9261\/files\/3639146859-0.jpg?v=1784241692","url":"https:\/\/www.bluevasebooks.com\/products\/mass-spectrometric-analysis-of-oligonucleotide-and-dna-adducts","provider":"Blue Vase Books","version":"1.0","type":"link"}