{"product_id":"rethinking-cancer-a-new-paradigm-for-the-postgenomics-era-vienna-series-in-theoretical-biology","title":"Rethinking Cancer: A New Paradigm for the Postgenomics Era (Vienna Series in Theoretical Biology)","description":"Leading scientists argue for a new paradigm for cancer research, proposing a complex systems view of cancer supported by empirical evidence.\n\nCurrent consensus in cancer research explains cancer as a disease caused by specific mutations in certain genes. After dramatic advances in genome sequencing, never before have we known so much about the individual cancer cell--and yet never before has it been so unclear what to do with this knowledge. In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. The contributors propose a complex systems view of cancer, presenting conceptual building blocks for a new research paradigm supported by empirical evidence.\n\nThe contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and non-coding DNA--the \"dark matter\" of our genome. They address the temporality of cancer progression, drawing on evolutionary theory and clinical experience. Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization.\u003cbr\u003eASIN: 0262045214\u003cbr\u003eVSKU: BVV.0262045214.G\u003cbr\u003eCondition: Good\u003cbr\u003eAuthor\/Artist:Strauss, Bernhard\u003cbr\u003eBinding: Hardcover\u003cbr\u003e\u003cb\u003eNote:\u003c\/b\u003e Any images shown are stock photographs and product may differ from what is shown.  \u003cbr\u003e\u003cb\u003eCondition Notes\u003c\/b\u003e: The item shows wear from consistent use, but it remains in good condition and works perfectly. All pages and cover are intact  including the dust cover, if applicable . Spine may show signs of wear. Pages may include limited notes and highlighting. May NOT include discs, access code or other supplemental materials.  \u003cbr\u003e","brand":"Blue Vase Books","offers":[{"title":"Default Title","offer_id":43337717383229,"sku":"BVV.0262045214.G","price":8.93,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0589\/4225\/9261\/files\/0262045214-0.jpg?v=1783891632","url":"https:\/\/www.bluevasebooks.com\/products\/rethinking-cancer-a-new-paradigm-for-the-postgenomics-era-vienna-series-in-theoretical-biology","provider":"Blue Vase Books","version":"1.0","type":"link"}